In this Review article, Soundarajan summarises the current state of chimeric antigen receptor (CAR) T-cell therapy for cancer, with a particular focus on the future opportunities and remaining challenges for this novel class of cancer therapeutics.

In this report, Bosa et al. present a case of primary Ewing's Sarcoma in the gallbladder with hepatic metastasis diagnosed via immunohistochemical findings. This primitive neuroectodermal tumor is a rare metastatic finding in the gallbladder in adults.

While the past ten years have yielded significant progress in neurosurgery, the prioritisation of global health outcomes and equity in neurosurgical care is a particularly valuable advancement due to the benefits yet to be gained. The appreciation of safe and effective neurosurgery as a key element of universal health coverage is highly encouraging as a sign of progress towards more equitable surgical care for patients around the world.