Ewing's sarcoma (SE) / primitive neuroectodermal tumor (PNET) occurs most often in soft tissues of the extremities and in the paravertebral areas. As far as we know, there are only two other reports in the gallbladder SE / PNET literature, however, this is the first metastatic case in a 58-year-old man. Microscopically, small round cell neoplasms showed intense positive immunoreactive activity for CD99, as well as for neuron-specific enoase and synaphysophine.

Abstract

Background: Acalculous cholecystitis makes up only 5-10% of all acute cholecystitis presentations and typically occurs in unwell patients with comorbidity.

Leprosy is a globally prevalent disease with a high rate of transmission, yet treatment remains difficult. In this article, Muhammad Luthfi reviews current progress of the LepVax vaccine, a novel strategy for preventing infection and reducing morbidity.

Simpson et al. describe a case of necrotising sialometaplasia – a rare but benign, self-limiting, inflammatory condition that can resemble malignant lesions both clinically and histopathologically.

In this Review article, Soundarajan summarises the current state of chimeric antigen receptor (CAR) T-cell therapy for cancer, with a particular focus on the future opportunities and remaining challenges for this novel class of cancer therapeutics.

In this report, Bosa et al. present a case of primary Ewing's Sarcoma in the gallbladder with hepatic metastasis diagnosed via immunohistochemical findings. This primitive neuroectodermal tumor is a rare metastatic finding in the gallbladder in adults.

While the past ten years have yielded significant progress in neurosurgery, the prioritisation of global health outcomes and equity in neurosurgical care is a particularly valuable advancement due to the benefits yet to be gained. The appreciation of safe and effective neurosurgery as a key element of universal health coverage is highly encouraging as a sign of progress towards more equitable surgical care for patients around the world.

Janvi Karia shares her reflections of working in ICU as a 5th year medical student during the COVID-19 pandemic with the CMJ.

Winner of the MedTech Foundation & Cambridge Medicine Journal Essay Competition 2021.

COVID-19 has fundamentally altered clinical practices and guidelines. This also applies to liver transplantation. In the UK, liver transplant activity has dramatically decreased during the early months of the pandemic. The traditional logic dictates that transplantation-related immunosuppression increases the risk of COVID-19 infection and entails sub-par clinical outcomes. However, theories remain theories without clinical evidence. This article examines whether such concerns justify reducing liver transplant activity.